A PHP Error was encountered

Severity: Warning

Message: json_decode() expects parameter 1 to be string, array given

Filename: helpers/youtube_helper.php

Line Number: 571

A PHP Error was encountered

Severity: Notice

Message: Undefined variable: video_list

Filename: helpers/youtube_helper.php

Line Number: 453

A PHP Error was encountered

Severity: Warning

Message: Cannot modify header information - headers already sent by (output started at /home/httpd/up-tube.com/content/html/system/core/Exceptions.php:185)

Filename: libraries/Tracker.php

Line Number: 47

The Neuroscience Of Addiction - With Marc | Conversation About Addiction With - At Up-Tube.com

The Neuroscience of Addiction - with Marc Conversation About Addiction with 9 months ago   1:00:48

The Royal Institution
Neuroscientist and former addict Marc Lewis makes the case that addiction isn't a disease at all, although it has been recently branded as such.
Watch the Q&A: https://up-tube.com/upvideo/cRwZv1BCaLL
Subscribe for regular science videos: http://bit.ly/RiSubscRibe

In recent decades doctors have branded addiction a brain disease, and treated it as such. But in this riveting and provocative talk, neuroscientist and former addict Marc Lewis makes the convincing case that addiction isn’t a disease at all. Using personal stories and robust science, he explains how addiction really impacts our brains, and how neuroplasticity and a developmental approach to treatment can help to overcome it.

Marc Lewis is a neuroscientist and professor of developmental psychology, recently at the University of Toronto, where he taught and conducted research from 1989 to 2010, and presently at Radboud University in the Netherlands. He is the author or co-author of over 50 journal publications in psychology and neuroscience, editor of an academic book on developmental psychology, and co-author of a book for parents. More recently he has written two books concerning addiction.

Subscribe for regular science videos: http://bit.ly/RiSubscRibe

The Ri is on Twitter: http://twitter.com/ri_science
and Facebook: http://www.facebook.com/royalinstitution
and Tumblr: http://ri-science.tumblr.com/
Our editorial policy: http://www.rigb.org/home/editorial-policy
Subscribe for the latest science videos: http://bit.ly/RiNewsletter

Comments 201 Comments

G Thomas
About halfway through he talks about addiction cycle, around 48:00 he starts talking about recovery
Built240 Built240
The true science of addiction is the Nuclear phosphoprotein Fos proto-oncogene. In the FOS family there are 4 genes.

DeltaFosB is a truncated splice variant of the FOSB gene(shortened coding sequence of genes that highly effect gene function.)

Anyway deltafosB is basically the brains molecular switch for addiction and various transcription factors like c-fos, CREB, deltaCREB, C/EBPbeta, AP-1, c-Jun and ep300 (or p300/Histone Acetyltransferace) which all effect gene expression as well.

It’s basically your brain learning to only function is this is this is this substance or action that renders many people (especially those with genetic mutations in the pathway) helpless as they cannot “try” or “want” to quit as their brain simply WILL NOT let them.

This is all obvious with our knowledge of genetics and epigenetics and should be pretty easy for science as they had plenty of time to develop novel compounds to counteract addiction but it seems they are slacking.

More focus needs to be put into other important areas besides the obvious dopamine, serotonin, NE, Gaba,etc.. more focus need to be on histone deacetylase inhibition, phosphodiesterase inhibition, regulation of Tyrosine Hydroxylase, wayyyy more research on Orexin and it’s Hypocretin receptors, more NMDA regulators, Calcium/calmodulin dependent protein kinases, Cell division protein kinases, Peroxisome proliferator activated receptor (PPAR) signaling, Trace amine associated receptors, Vanilloid receptors(hardly anything on this which is negligent as it relates to endorphins), much more on adrenergic receptors, vesicular monoamine transporters, Wnt signaling, VEGF signaling, and definitely more on melatonergic agonism as the circadian rhythm regulates everything.
Jaime Cundy
Is there any link to the data he quotes about the majority of people who become addicted quitting?
PEMF Devices
Do we agree that all addicts need to be and should be saved? :P
Asley devin
You can stop your addiction now! :) https://bit.ly/2Yf15XE
Eric Belsterling
Lewis is quite the inspiration; a human being who overcame his addictions and transformed himself into a world class neuroscience. His model of addiction as being a “pathological overlearning” is excellent and I believe is a great addition to the body of research already established in addiction science. I’m also an avid fan of Dr. Kevin McCauley, who explains what constitutes something as a disease. According to McCauley the disease model developed through Germ Theory, which states there is a defect in the organ which leads to signs and symptoms. The defect would occur in reward pleasure pathway, and can be amended. This would then impact the signs and symptoms. I really like Lewis, however, the argument if we say it is a pathological overlearning, still requires the same type of treatment, CBT at first, then the deep trauma, attachment wounding repeat and resolution. I look at disease as dis-ease. Again, Lewis is a powerhouse and an inspiration.
Tim Counts
Conveniently ignoring 70 years of research by endless institutions around the world, does not leave you in a great place to have a hypothesis.
It is also very dangerous for everyone.
Your A.A. statistics come from a Psychology Today article, they stand without one single source for the percentage of success rates in A.A. They were guessing, as no one tracks main stream A.A. members.
Anyone can get addicted emotionally to drugs, alcohol, video games, relationships, gambling, etc. That does not necessarily make you an addict comparable to say the real opioid and or alcohol addict. And yes, the brain will reflect many of the same changes as a real alcoholic or addict. Old news.
We have so little information on the brain, any conclusions in this generation is a leap of faith and little else. Reference your own professional field.
Comparing emotional addictions to drug addiction and alcoholism is extremely dangerous for a layman in any field of study.
We have very little long term, in-depth research for drug addiction. We have two hundred plus years of serious clinical research on alcoholism along with the last seventy years of serious and intense scientific study including biology, DNA, brain scans.
While we have almost no research for many of the drugs being abused, we do have some close correlations of opioid addiction and alcoholism.
Is there any evidence to support natural hereditary predispositions to gambling, sex, food, relationship, gaming addictions other than nurture?
We have known since the 1960 studies in Europe that alcoholism has a genetic factor. We now have a DNA identification as of 2013 (?).
Alcoholics have biological differences in their digestive system that cause them to process alcohol differently than normal people. This is hard science without dispute for decades.
There are several other agreed upon differences in the predisposed alcoholic body that are without dispute, e.g. dopamine levels, etc.
Can we make many correlations of the real alcoholic to the sex addict or the shopaholic, absolutely. When was the last time a sex or gaming addict died while detoxing from their joystick?
Does the gamer have a physical craving for the next game after the first game? That is what separates the emotional addiction to the real addict or alcoholic. It is a habitual brain problem as well. No one has ever argued differently.
About 10% of America, 12% worldwide are predisposed to alcoholism. Some will have problems from the first drink, the Type B alcoholic, others will advance their drinking to the point they develop a physical craving, the Type A alcoholic. Both are predisposed.
Everyone who has had a hip replacement, an accident, broken bone, that was given morphine in the hospital for two or three days is technically addicted to opioids. The doctor starts reducing the dosage and detoxes them off the drug. 90% of America goes on with their lives while about ten percent cannot stop themselves going back to the drug regardless of their desire to stop.
Are they habitually addicted in the first week or is it a physical and biological reaction? I think we can all guess at the answer but I suspect science will get down to the same answers they found for the real alcoholic in the 1970's and since.
I strongly suggest you read the A.A. Big Book, paying close attention to the descriptions of the "problem drinker" V the "real alcoholic". There are numerous descriptions and case stories to help you along the journey. These are the same descriptions that so enlightened the medical and scientific research folks in the 1940's when it was first published. Yale university and Rutgers in the beginning. They did not understand the distinction and their research could not come to any conclusions until they started separating the groups and could identify the two.

While the statistics in mainstream A.A. may look grim for their open meetings, let us remember that half the people being forced into the rooms of
A.A. by the courts, ignorant doctors, uneducated therapist, for profit treatment industry and angry partners, it does not represent the actual success rates of the A.A. program of recovery. It does represent a plethora of misinformed professionals.
The Physicians Health Program, started in the 1960's and today in every state in the U.S., the Airline Unions, Auto Unions, etc, have success rates of 70 to 95%, after five years, all using the Program of Recovery from A.A. The biggest difference these organized recovery plans have, they can force the employee, doctor, lawyer, pilot into a two year program and hold them accountable.
We have known since the 1950's that we must have full cooperation and commitment from the alcoholic in A.A. for two years, to achieve a five year plus recovered alcoholic. That brings us back to the brain problem of the habitual thinking and actions of the addiction.
I would argue that it takes longer to change the habitual personal negativity of a real alcoholic than the average gamer or sex addict but the problem does have a solution, we have seen it millions of times.
A.A. was never meant to be a meeting room of amateur therapist where folks discuss their daily affairs and problems. It was meant to be a room where they discussed how to get the message to the still suffering alcoholic and the community at large. Some of those rooms still exist today.
If you have a problem with alcohol and want to fix it, contact your local A.A. hotline and ask for a Big Book study or ask them where the BB Thumper's are. There is help.
Richard Thompson
I wouldn't say that the 12-step programs are the only way to recovery, but I will say that it works very well for me, and has for many years. A common misconception about AA and NA is that the people who utilize those means of recovery are in a constant state of barely holding on their recovery, needing constant reminders of what might happen if they use again. That's not been my experience at all. It's true that in early recovery, those are helpful, but an addict who only focuses on what would happen as a result of relapse is an addict who is much the same person as they were before, only without the drug flowing through their system. The 12-step programs are frameworks for real change. All one has to do is look at the other steps after the first step. It is a process of getting out of an extreme self- obsession and thereby learning to have a more rational, balanced sense of self. It's a reintegration with society. I don't care what anyone says, there is no person that can relate to addiction like someone who has experienced it themselves. A major part of the 12-step programs is addicts who have time in recovery working with other addicts. We have a saying; "You have to give it away to keep it". It would be great if people could go to a counselor every day, but that's generally not possible unless one is very wealthy. There are NA meetings every day of the week where I live, and even after years, I still average five each week. Not because I have to make that many to stay clean, but because I WANT to! I want to be there for those who come brand new (or come back after brutal relapse) I consider it a tremendous blessing to have the opportunity to help these people, to be an example to them, and it is such a wonderful thing to watch people have positive change in their lives, re-enter the job force, mend relations with families, and turn into such different people than they were, to the point that they become almost unrecognizable compared to their former selves, physically, mentally, and yes, spiritually. I should note here that the twelve-step programs are not religious programs. There is no compulsion for religious affiliation of any kind, and AA and NA are in no way allied with any religious or other outside entities. Each person is permitted and encouraged to form their own opinion of a "higher power". Powerless over my addiction? You bet! I've proved that enough to know beyond any shadow of a doubt that if I take any mood-altering substance, I will be right back on that other track, and the results are going to be devastating and immediate. It's black and white, night and day for me. What's odd is that the simple undeniable knowledge of that fact is not enough in the long run for me to manage to stay clean long-term. I have to guard myself against falling into that self-centered mindset that is so prevalent with people like me, and the best way I know how to do that is to be meaningfully involved in other people's lives and becoming a responsible, acceptable and productive member of society. NA has given me a way to do that within the framework of the 12 steps, and a wonderful group of extremely close friends who know me well enough and care enough about me go out of their way for me. We stick together. We don't do it alone.
The disease model has been pounded at me [I am an addictionologist] but I could never explain why the treatment [i.e.,wanting to get better] could put "the disease" in remission. We don't tell cancer patients that they will get better if they want it bad enough.
MorbidSaint 666
I've quit cocaine few months ago, but struggling with alcohol, that's the tough shit, especially when you're alone af
Juliette Lê
Baclofen is NOT a benzo!
Andrew Dwight
Love you channel
Please check out my new book, it will change the way you view addiction!
Amanda Gill
The stregnth of sin is the law Bible says
Martin Roy
I've been working as an addictions counselors in an intense 8 weekend substance abuse treatment facility for federal parolees in Canada and I never bought the "addiction is a disease" modality. Here, our treatment philosophy is based on the social learning theory in that addiction is a learnt behaviour. When Mark wrote The Biology of Desire, it reinforced exactly how we approach addiction. We'd be doing the parolees a disservice if we told them they were sick and they're was no cure. We're even encouraging our clients to read it. We need more people like Mark Lewis to destroy this house of cards that's been built and the crap the medical establishment has been peddling since the 1950s.
I am very grateful for this video. I'm currently in a masters program for counseling Psychology, and I'm taking Intro to Addictions. We are taught that it is an undeniable fact that Substance Use Disorder is strictly a "disease". I tried to discuss how this might not be the case with my professor and was told that I cannot deny the "science". Well, I think I might send him this video because it's very compelling. I agree we should end the war on drugs and work to reduce the stigma. At the same time, if this is something people can overcome and it's more complex than it being just a "brain disease", then I think it's important that individuals do feel a sense of agency and power over their lives. I agree that saying substance use disorder is "strictly a disease" can actually hinder some people's ability to make progress.
Varunpreet Singh
The overlap of unacceptable (drugs , over indulgence ) & the acceptable ( smoking , drinking , binge eating maybe) is uber important to understand in its subtlety / variableness; and Marc Lewis gave very good tools to envision them ; hence practically take ownership in why & how and what can be done at individual level thereon ...

Simply Brilliant ... Two Thumbs up !
Radoslaw Jasionowski
Absolutely correct and evidence based approach towards addictions. It is all about habits and skills and neuroplasticity. Love is addiction like amphetamine, food is addiction, anything is addiction that rewards us, even going to gym. Look how many people run each day 5 km and become hooked and addicted to it. Their knees and joints become problem, they cant stop! Spend thousands on new gears, cant feel relaxed without running or going to gym, where often they do it with wrong techniques, but everyone tells them that they are "healthy, sporty people"- but if nature wanted you to be a racing horse then it would provide you with better joints;)
random bastard
Hello I am a heroin and crack addict for about 15 years, I'm from the midlands uk, I would really like to offer myself for research through brain scans etc, and donate my body to the field once I die I was a high functioning addict till very recently.
Can I humbly ask for someones guidance or point me in the right direction, I suppose I should contact my local university or one who special in the field.
i will hawe a name for it Kajanderia. its spesific.
Add Reply

Conversation About Addiction with The Neuroscience of Addiction - with Marc 9 months ago   55:54

Dr. Mate is a best-selling author/speaker on the subject of addiction, stress, childhood development and other topics. Arold Langeveld is a nonduality teacher and addiction counselor in the Netherlands. He worked in several addiction clinics using nonduality principles in his therapy. In this panel, the two will address how addiction is not about the substance or activity, but about the pain of the individual addicted. Dr. Mate will provide his expertise and vast working knowledge of the brain and child development and other issues related to addiction. Arold Langeveld plays a key role in the nonduality movie 'All about Nothing'.

Gabor Maté M.D. is a physician and best-selling author whose books
have been published in twenty languages internationally. His interests
include child development, the mind-body unity in health and illness, and the treatment of addictions. Gabor has worked in palliative care
and as a family physician, and for fourteen years practiced addiction
medicine in Vancouver’s Downtown Eastside. As a speaker he regularly addresses professional and lay audiences throughout North
America. His most recent book, In The Realm of Hungry Ghosts: Close Encounters With Addiction, won the Hubert Evans Prize for literary non ction. He is Adjunct Professor in the Faculty of Criminology, Simon Fraser University.

Related Videos